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MethodsThe study protocol has been published elsewhere.14 In brief, we used a prospective, parallel group, single blinded, placebo controlled design. The patients were randomised to one of three treatment arms: ibuprofen 600 mg three times daily, amoxicillin clavulanic acid 500 mg/125 mg three times daily, or placebo three times daily for 10 days. The pharmacy unit of the Hospital Vall d’Hebron (Barcelona, Catalonia) prepared the drugs. A block randomisation method was used and the various treatments and placebo blocks were then issued with a drug number and assigned to consecutive patients in sequential order. https://www.hp-laptop-batteries.co.uk Patients were masked to treatment allocation. Twenty five general practitioners from nine primary care centres in Catalonia recruited participants from April 2010 to January 2012.